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In respiratory mucosa, TFSB prevented LPS/cigarette smoke-induced airway inflammation in mice and HBE16 bronchial epithelial cells by suppressing the expression of IL-1β, IL-6, chemokine (C-X-C motif) ligand 1 (CXCL1), and mucin 5 subtype AC (MUC5AC) through inhibition of extracellular regulated protein kinases (ERK), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and protein kinase C-alpha (PKCα) pathways, as supported by molecular docking studies showing binding affinities to upstream kinases ( 3.3 Modulating immune cell responses and cytokine networks Following initial signaling, inflammation is characterized by the recruitment and activation of specific immune cells and the release of cytokines ( 3.3.1 Balancing immune responses in cutaneous inflammation Skin inflammation involves dysregulated crosstalk between various immune cells (Zouboulis et al., 2022 RIZTICS L-Glutathione Cream for Skin Brightening with Vitamin C & Alpha Arbutin Helps in Fade Dark Spots & Anti-Ageing 25 gm Unisex Beauty Size:50ml n3_antioxidant formulas https://lookaside.fbsbx.com/lookaside/crawler/media/?media_id=1203243278060469&get_thumbnail=1
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