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Alternatively, considering the reported bioavailability of 17.0–31% for mitragynine in rats 32 and 3–17% in human

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Nrf2 binding to antioxidant response elements leads to the transcription of genes that encode antioxidant proteins such as hemoxygenase-1 (HO-1), superoxide dismutase-2 and glutathione peroxidase [104]