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In one program, a separate NNMT inhibitor reduced 1-methylnicotinamide levels and improved insulin sensitivity and glucose tolerance in DIO mice, with these effects absent in NNMT-knockout animals
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381 Canakinumab (Ilaris) is a monoclonal antibody that inhibits interleukin-1β, an inflammatory cytokine produced in response to NLRP3 inflammasome activation and closely linked to cardiovascular disease
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