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After this initial drop, WT mice maintained a stable level of potentiation throughout the recording period, whereas HDAC9 ⁻/⁻ mice continued to decline, with synaptic responses approaching baseline levels by the end of the session (Fig

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Consequently, it is impossible to determine whether IN GHK-Cu restored the aged hippocampus to a younger baseline, or if it simply pushed the tissue into a novel, alternative compensatory state that functions better in a spatial maze