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In addition, BSO decreased the intensity of Ki67 staining and increased that of 4-HNE staining in tumors with high ACTL6A expression, but this trend was not observed in PDX tumors with low ACTL6A expression (Supplementary Fig 8b)
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Mechanistically, PARP1 is associated with the stabilizing of HIF-1α (Hulse et al., 2018), which plays a vital role in melanocyte transformation and represents an essential feature in malignant tumor growth, including melanoma (Malekan et al., 2021)
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