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In diazepam chronically treated mice, it attenuated diazepam tolerance (provoked by later acute administration of diazepam together with convulsant) and postponed physical dependence/withdrawal effects (provoked by later administration of isoniazid)
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Dietary tryptophan is metabolized by the gut microbiota into aryl hydrocarbon receptor agonists such as indoxyl-3-sulfate and indole-3-propionic acid, which can modulate astrocyte inflammatory function trough limiting NF-κB activation in a suppressor of cytokine signalling 2-dependent manner (Rothhammer et al
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