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Reduced microbial diversity—especially a loss of anti-inflammatory bacteria like Faecalibacterium prausnitzii —is associated with neuroinflammation and heightened pain sensitivity ( 6.2 The role of GLP-1 receptor agonists Glucagon-like peptide-1 receptor (GLP-1R) agonists present a promising avenue for chronic pain management, as preclinical studies demonstrate their role in modulating neuroinflammation, central sensitization, and pain signaling pathways

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