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The levels of cell cycle inhibitors P21 CIP1 and P27 Kip1 were also altered in Gstp1/2 −/− reinforcing the conclusion of an impaired progression in G1 phase in mutant mice (Figure 5c)
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Role of Antioxidants during Chelation Induction of reactive oxygen species by metals and subsequent depletion of antioxidant cell defenses can result in disruption of the pro-oxidant/antioxidant balance in tissues [203]
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