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Some patients report several symptoms, while others have mild reactions or none that are noticeable

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enzyme induction, hepatic disease: affects clearance of drugs with low extraction ratios): Examples -- Social factors : Tobacco smoke induces some hepatic microsomal drug metabolizing enzyme isoforms (CYP1A1, CYP1A2, and possibly CYP2E1) Chronic ethanol use induces CYP2E1 Dietary considerations: Grapefruit juice contains chemicals that are potent inhibitors of CYP3A4 localized in the intestinal wall mucosa Cruciferous vegetables such as brussels sprouts, cabbage, cauliflower and hydrocarbons present in charcoal-broiled meats can induce CYP1A2