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Tf moves from the plasma membrane clathrin-coated pits to early endosomes, and after acidification and iron dissociation, apoTf is directed to recycling endosomes for trafficking to the cell surface and release

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Example: a snare polypectomy in the sigmoid colon (45385, primary, no modifier) and a biopsy of an ulcerated lesion in the ascending colon (45380, modifier 59 for commercial or modifier XS for Medicare)