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This review discusses mechanisms and applications of small molecules in generating high-quality hepatocytes via differentiation and reprogramming and in improving hepatocyte engraftment and repopulation (Figure 1)
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When extracellular levels of copper are increased, such as under conditions of high dietary copper intake, CTR1 is rapidly internalized via clathrin-mediated endocytosis and the copper transporter does not return to the plasma membrane until extracellular copper levels are decreased (Clifford et al., 2016
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