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Oxidative stress doesn't just affect the body; it profoundly impacts the brain. As the brain consumes enormous amounts of energy each day, it becomes especially vulnerable to oxidative damage over time, influencing
(108) found that long-term fasting-mimicking diet (FMD) cycles reduced hippocampal Aβ load and tau hyperphosphorylation in E4FAD and 3xTg AD mouse models, enhanced neurogenesis, reduced the number of microglia, and decreased the expression of neuroinflammatory genes, including the superoxide-producing NADPH oxidase (Nox2)
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A 2025 systematic review in HSS Journal screened 36 BPC-157 studies published between 1993 and 2024 and found 35 preclinical and one (retrospective) clinical study
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