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Lymphocytes secrete specific enzymes to disrupt the ECM, including: (i) heparinase (HPSE), an endoglucuronidase that cleaves heparan sulfate side chains of heparan sulfate proteoglycans (137), (ii) hyaluronidase, an endoglycosidase that cleaves glycosidic bonds of hyaluronic acid (138), and (iii) matrix metalloproteinases (MMPs), endopeptidase proteases that cleave the majority of ECM and non-ECM components ( Figure 2 )
Glow and hydrate toner
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