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reported 2-aminoimidazole alkaloid naamidine A 61 , which was isolated from a Fijian Leucetta species sponge as an inhibitor of the epidermal growth factor (EGF) receptor.196 In this part of the work, the authors claimed that the compound exhibited a potent ability to inhibit the EGF signaling pathway and was more specific for the EGF-mediated mitogenic response than for the insulin-mediated mitogenic response
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In cases in which the model provided an even split of stage classifications for a region within a decade ( n = 2: Poland, 2010s
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