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Moreover, SIRT -1 reduces ferroptosis by activating autophagy ( N-acetylcysteine is the cornerstone treatment for hepatotoxicity following APAP overdose
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During alcohol abuse, the demand for ketone bodies in the brain increases, and adaptation to repeated alcohol intake occurs, while acetate levels decline during withdrawal, and supplementation of ketone bodies through a KD may alleviate withdrawal symptoms due to the sudden shift in metabolic status (106)
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