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Other ALDH2 approaches: Many investigational drugs showed promise in pre-clinical studies, including selective and reversible ALDH2 inhibitors (e.g., ANS-6637) and genetic targeting of liver ALDH2 messenger RNA to locally reduce hepatic ALDH2 expression (305, 306)

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Unknown Long-Term Effects : Long-term risks remain unclear because controlled human studies have not established durable safety outcomes, organ effects, cancer-related concerns, or interaction risks