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Frontiers | Research progress on peptides that inhibit melanin synthesis

GHK prevented an increase in MCP-1 and nitrotyrosine levels in the hippocampus of sleep-deprived mice suggesting that inflammatory and reactive nitrogen/oxygen species activity could be therapeutic targets for learning impairment associated with short-term sleep deprivation

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In experiments using NO synthase inhibitors (such as L-NAME) and NO precursors (such as L-arginine), BPC-157 appeared to counteract the harmful effects of NO blockade and to modulate NO-dependent responses in the vasculature and gastrointestinal tract